INHIBITION OF A RECEPTOR-OPERATED CALCIUM-CHANNEL IN PIG AORTIC MICROSOMES BY CYCLIC GMP-DEPENDENT PROTEIN-KINASE

被引：21

作者：

BLAYNEY, LM

GAPPER, PW

NEWBY, AC

机构：

来源：

BIOCHEMICAL JOURNAL | 1991年 / 273卷

关键词：

D O I：

10.1042/bj2730803

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have further characterized a putative receptor-operated Ca2+ channel that is activated by histamine and guanosine 5'-[beta-gamma-imido]triphosphate. Insensitivity to verapamil, diltiazem or nicardipine, but inhibition by Ni2+ and SK&F 96365, further identify the channel with receptor-mediated Ca2+ entry in intact cells. Inhibition of the channel by cyclic-GMP-dependent protein kinase may contribute to vascular relaxation in response to nitrovasodilators.

引用

页码：803 / 806

页数：4

共 23 条

[1] A NOVEL RECEPTOR-OPERATED CA-2+-PERMEABLE CHANNEL ACTIVATED BY ATP IN SMOOTH-MUSCLE [J].