DESENSITIZATION OF HUMAN-PLATELETS BY PLATELET ACTIVATING FACTOR

被引：54

作者：

CHESNEY, CM ^{[1
]}

PIFER, DD ^{[1
]}

HUCH, KM ^{[1
]}

机构：

[1] BAPTIST MEM HOSP, DEPT PATHOL, MEMPHIS, TN 38146 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1985年 / 127卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(85)80120-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human platelets are less responsive to PAF [platelet-activating factor] at 37.degree. than at 25.degree. C. They can be desensitized to the effects of PAF by preexposure to small concentrations. In both cases, desensitization appears to be accompanied by a decreased affinity of the high affinity site for PAF, rather than by loss of binding sites. Alteration of a metabolic step subsequent to binding cannot be excluded, but platelets show normal response to a variety of other agents under the conditions resulting in desensitization of platelets to PAF.

引用

页码：24 / 30

页数：7

共 16 条

[1] LEUKOCYTE-DEPENDENT HISTAMINE-RELEASE FROM RABBIT PLATELETS - ROLE OF IGE, BASOPHILS, AND A PLATELET-ACTIVATING FACTOR [J].