COPII - A MEMBRANE COAT THAT FORMS ENDOPLASMIC RETICULUM-DERIVED VESICLES

被引：31

作者：

BARLOWE, C

机构：

来源：

FEBS LETTERS | 1995年 / 369卷 / 01期

关键词：

INTRACELLULAR TRANSPORT; VESICLE BUDDING; COAT PROTEIN; ENDOPLASMIC RETICULUM;

D O I：

10.1016/0014-5793(95)00618-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vesicle budding from the endoplasmic reticulum (ER) has been reconstituted with washed membranes and three soluble proteins: Sec13 complex, Sec23 complex and the small GTPase Sar1p. The proteins that drive this cell-free vesicle budding reaction form an similar to 10 nm thick electron dense coat on ER-derived vesicles. Although the overall mechanism of membrane budding driven by various cytoplasmic coats appears similar, the constituents of this new membrane coat are molecularly distinct from the non-clathrin coat (COP) involved in intra-Golgi transport and the clathrin-containing coats. The new vesicle coat has been termed COPII.

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页码：93 / 96

页数：4

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