COMPACTIN (ML-236B) AND RELATED-COMPOUNDS AS POTENTIAL CHOLESTEROL-LOWERING AGENTS THAT INHIBIT HMG-COA REDUCTASE

被引：262

作者：

ENDO, A

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1985年 / 28卷 / 04期

关键词：

D O I：

10.1021/jm00382a001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：401 / 405

页数：5

共 45 条

[1] DIHYDROMEVINOLIN, A POTENT HYPOCHOLESTEROLEMIC METABOLITE PRODUCED BY ASPERGILLUS-TERREUS [J].

ALBERSSCHONBERG, G ;

JOSHUA, H ;

LOPEZ, MB ;

HENSENS, OD ;

SPRINGER, JP ;

CHEN, J ;

OSTROVE, S ;

HOFFMAN, CH ;

ALBERTS, AW ;

PATCHETT, AA .

JOURNAL OF ANTIBIOTICS, 1981, 34 (05) :507-512

[2] MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT [J].

ALBERTS, AW ;

CHEN, J ;

KURON, G ;

HUNT, V ;

HUFF, J ;

HOFFMAN, C ;

ROTHROCK, J ;

LOPEZ, M ;

JOSHUA, H ;

HARRIS, E ;

PATCHETT, A ;

MONAGHAN, R ;

CURRIE, S ;

STAPLEY, E ;

ALBERSSCHONBERG, G ;

HENSENS, O ;

HIRSHFIELD, J ;

HOOGSTEEN, K ;

LIESCH, J ;

SPRINGER, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07) :3957-3961

[3] MEVINOLIN AND COLESTIPOL STIMULATE RECEPTOR-MEDIATED CLEARANCE OF LOW-DENSITY LIPOPROTEIN FROM PLASMA IN FAMILIAL HYPERCHOLESTEROLEMIA HETEROZYGOTES [J].

BILHEIMER, DW ;

GRUNDY, SM ;

BROWN, MS ;

GOLDSTEIN, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (13) :4124-4128

[4] CRYSTAL AND MOLECULAR-STRUCTURE OF COMPACTIN, A NEW ANTIFUNGAL METABOLITE FROM PENICILLIUM-BREVICOMPACTUM [J].

BROWN, AG ;

SMALE, TC ;

KING, TJ ;

HASENKAMP, R ;

THOMPSON, RH .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (11) :1165-1173

[5] REGULATION OF PLASMA-CHOLESTEROL BY LIPOPROTEIN RECEPTORS [J].

BROWN, MS ;

KOVANEN, PT ;

GOLDSTEIN, JL .

SCIENCE, 1981, 212 (4495) :628-635

[6]

BROWN MS, 1978, J BIOL CHEM, V253, P1121

[7]

CARSON DD, 1979, P NATL ACAD SCI USA, V76, P5709, DOI 10.1073/pnas.76.11.5709

[8]

CIEGLER A, 1971, MICROBIAL TOXINS, V5

[9]

COHEN DC, 1982, J BIOL CHEM, V257, P9429

[10]

COHEN DC, 1982, J BIOL CHEM, V257, P1106

← 1 2 3 4 5 →