THE FAS DEATH FACTOR

被引：3810

作者：

NAGATA, S ^{[1
]}

GOLSTEIN, P ^{[1
]}

机构：

[1] CNRS MARSEILLE LUMINY, INSERM, CTR IMMUNOL, F-13288 MARSEILLE 9, FRANCE

来源：

SCIENCE | 1995年 / 267卷 / 5203期

关键词：

D O I：

10.1126/science.7533326

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and Fast are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.

引用

页码：1449 / 1456

页数：8

共 146 条

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