QUANTIFICATION OF GLUTAMATE, GLUTAMINE, AND OTHER METABOLITES IN INVIVO PROTON NMR-SPECTROSCOPY

被引：21

作者：

BOVEE, WMMJ

机构：

[1] Delft University of Technology, Department of Applied physics, Delft, 2600 GA

来源：

NMR IN BIOMEDICINE | 1991年 / 4卷 / 02期

关键词：

D O I：

10.1002/nbm.1940040209

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A reliable quantification of in vivo H-1 MRS spectra is hampered by extensive line overlap, by intensity distortions due to the water suppressing pulse sequence and complex modulation patterns of J-coupled spins, and by deviations between the experimental and model lineshapes in computer fitting programs. By correcting the experimental lineshape, using a suitable pulse sequence, and incorporating prior knowledge about the spin systems and the intensity distortions, a sufficient quantification is possible. If reliable T2 values are available absolute concentrations can be determined.

引用

页码：81 / 84

页数：4

共 13 条

[1]

ABRAGAM A, 1961, PRINCIPLES NUCLEAR M, P480

[2]

BARKHUYSEN H, 1986, J MAGN RESON, P371

[3]

BENDALL MR, 1983, J MAGN RESON, V53, P365, DOI 10.1016/0022-2364(83)90211-1

[4] SELECTIVE FOURIER-TRANSFORM LOCALIZATION [J].