A HUMAN ONCOGENE FORMED BY THE FUSION OF TRUNCATED TROPOMYOSIN AND PROTEIN TYROSINE KINASE SEQUENCES

被引：732

作者：

MARTINZANCA, D ^{[1
]}

HUGHES, SH ^{[1
]}

BARBACID, M ^{[1
]}

机构：

[1] FREDERICK CANC RES FACIL, BASIC RES PROGRAM, GENE EXPRESS SECT, FREDERICK, MD 21701 USA

来源：

NATURE | 1986年 / 319卷 / 6056期

关键词：

D O I：

10.1038/319743a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule.

引用

页码：743 / 748

页数：6

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