PRINCIPLES OF CDK REGULATION

被引：2956

作者：

MORGAN, DO ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

来源：

NATURE | 1995年 / 374卷 / 6518期

关键词：

D O I：

10.1038/374131a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

As hey regulators of the cell cycle, the cyclin-dependent kinases must be tightly regulated by extra- and intracellular signals. The activity of cyclin-dependent kinases is controlled by four highly conserved biochemical mechanisms, forming a web of regulatory pathways unmatched in its elegance and intricacy.

引用

页码：131 / 134

页数：4

共 77 条

[1] MECHANISMS THAT HELP THE YEAST-CELL CYCLE CLOCK TICK - G2 CYCLINS TRANSCRIPTIONALLY ACTIVATE G2 CYCLINS AND REPRESS G1 CYCLINS [J].

AMON, A ;

TYERS, M ;

FUTCHER, B ;

NASMYTH, K .

CELL, 1993, 74 (06) :993-1007

[2] CLOSING THE CELL-CYCLE CIRCLE IN YEAST - G2 CYCLIN PROTEOLYSIS INITIATED AT MITOSIS PERSISTS UNTIL THE ACTIVATION OF G1 CYCLINS IN THE NEXT CYCLE [J].

AMON, A ;

IRNIGER, S ;

NASMYTH, K .

CELL, 1994, 77 (07) :1037-1050

[3] MECHANISMS OF P34CDC2 REGULATION [J].

ATHERTONFESSLER, S ;

PARKER, LL ;

GEAHLEN, RL ;

PIWNICAWORMS, H .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (03) :1675-1685

[4] CELL-CYCLE REGULATION OF THE P34(CDC2) INHIBITORY KINASES [J].

ATHERTONFESSLER, S ;

LIU, F ;

GABRIELLI, B ;

LEE, MS ;

PENG, CY ;

PIWNICAWORMS, H .

MOLECULAR BIOLOGY OF THE CELL, 1994, 5 (09) :989-1001

[5] TUMOR-SUPPRESSOR GENES - OPEN QUESTIONS ON P16 [J].

BONETTA, L .

NATURE, 1994, 370 (6486) :180-180

[6] EXPRESSION AND ACTIVITY OF P40(MO15), THE CATALYTIC SUBUNIT OF CDK-ACTIVATING KINASE, DURING XENOPUS OOGENESIS AND EMBRYOGENESIS [J].

BROWN, AJ ;

JONES, T ;

SHUTTLEWORTH, J .

MOLECULAR BIOLOGY OF THE CELL, 1994, 5 (08) :921-932

[7] IDENTIFICATION OF A GENE NECESSARY FOR CELL-CYCLE ARREST BY A NEGATIVE GROWTH-FACTOR OF YEAST - FAR1 IS AN INHIBITOR OF A G1 CYCLIN, CLN2 [J].

CHANG, F ;

HERSKOWITZ, I .

CELL, 1990, 63 (05) :999-1011

[8] NEGATIVE REGULATION OF THE WEE1 PROTEIN-KINASE BY DIRECT ACTION OF THE NIM1/CDR1 MITOTIC INDUCER [J].

COLEMAN, TR ;

TANG, ZH ;

DUNPHY, WG .

CELL, 1993, 72 (06) :919-929

[9] CRYSTAL-STRUCTURE OF CYCLIN-DEPENDENT KINASE-2 [J].

DEBONDT, HL ;

ROSENBLATT, J ;

JANCARIK, J ;

JONES, HD ;

MORGAN, DO ;

KIM, SH .

NATURE, 1993, 363 (6430) :595-602

[10] EFFECTS OF PHOSPHORYLATION BY CAK ON CYCLIN BINDING BY CDC2 AND CDK2 [J].

DESAI, D ;

WESSLING, HC ;

FISHER, RP ;

MORGAN, DO .

MOLECULAR AND CELLULAR BIOLOGY, 1995, 15 (01) :345-350

← 1 2 3 4 5 6 7 8 →