BIOCHEMISTRY OF NITRIC-OXIDE AND ITS REDOX-ACTIVATED FORMS

被引：2362

作者：

STAMLER, JS

SINGEL, DJ

LOSCALZO, J

机构：

[1] HARVARD UNIV,BROCKTON W ROXBURY VET ADM MED CTR,SCH MED,CARDIOL SECT,BOSTON,MA 02115

[2] HARVARD UNIV,DEPT CHEM,CAMBRIDGE,MA 02142

[3] BRIGHAM & WOMENS HOSP,DEPT MED,DIV CARDIOVASC,BOSTON,MA 02115

来源：

SCIENCE | 1992年 / 258卷 / 5090期

关键词：

D O I：

10.1126/science.1281928

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nitric oxide (NO.), a potentially toxic molecule, has been implicated in a wide range of biological functions. Details of its biochemistry, however, remain poorly understood. The broader chemistry of nitrogen monoxide (NO) involves a redox array of species with distinctive properties and reactivities: NO+ (nitrosonium), NO., and NO- (nitroxyl anion). The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.

引用

页码：1898 / 1902

页数：5

共 99 条

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