LOCALIZED H-1-NMR SPECTROSCOPY IN CANAVANS DISEASE - A REPORT OF 2 CASES

被引：79

作者：

AUSTIN, SJ

CONNELLY, A

GADIAN, DG

BENTON, JS

BRETT, EM

机构：

[1] LONDON HOSP,DEPT PEDIAT,LONDON E1 1BB,ENGLAND

[2] HOSP SICK CHILDREN,DEPT CLIN NEUROL,LONDON WC1N 3JH,ENGLAND

来源：

MAGNETIC RESONANCE IN MEDICINE | 1991年 / 19卷 / 02期

关键词：

D O I：

10.1002/mrm.1910190235

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Two children with Canavan's Disease, an autosomal recessive leukodystrophy, were studied by localized 1H spectroscopy. The N‐acetylaspartate (NAA) signal intensity was high relative to other metabolite signals, and the signal intensity from choline‐containing compounds was low. These findings are discussed in relation to a possible role for NAA in normal myelination. © 1991 Academic Press, Inc. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company

引用

页码：439 / 445

页数：7

共 25 条

[1]

ALLEN IV, 1984, GREENFIELDS NEUROPAT, P374

[2] ACETYL TRANSPORT MECHANISMS - METABOLISM OF N-ACETYL-L-ASPARTIC ACID IN NON-NERVOUS TISSUES OF RAT [J].