MANIPULATION OF COSTIMULATORY SIGNALS TO ENHANCE ANTITUMOR T-CELL RESPONSES

被引：148

作者：

ALLISON, JP

HURWITZ, AA

LEACH, DR

机构：

[1] Cancer Research Laboratory, Department of Molecular and Cell Biology, University of California, Berkeley

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 05期

关键词：

D O I：

10.1016/0952-7915(95)80077-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One of the major goals of tumor immunotherapy is the induction of tumor-specific T-cell responses that will be effective in eradicating disseminated tumors. Emerging information on the role of costimulatory molecules in T-cell activation offers several new strategies for enhancing antitumor responses, including the induction of expression of costimulatory molecules on tumor cells, enhancement of the presentation of transferred tumor antigen by host antigen-presenting cells, and ex vivo antigen priming of autologous antigen-presenting cells.

引用

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页码：682 / 686

页数：5

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