SOLUBLE INTERCELLULAR-ADHESION MOLECULE 1-IMMUNOGLOBULIN-G1 IMMUNOADHESIN MEDIATES PHAGOCYTOSIS OF MALARIA-INFECTED ERYTHROCYTES

被引：29

作者：

STAUNTON, DE

OCKENHOUSE, CF

SPRINGER, TA

机构：

[1] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

[2] WALTER REED ARMY MED CTR,WASHINGTON,DC 20307

[3] WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1992年 / 176卷 / 05期

关键词：

D O I：

10.1084/jem.176.5.1471

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe an immunoadhesin molecule containing intercellular adhesion molecule 1 (ICAM-1) molecularly fused to hinge and C(H)2 and C(H)3 domains of the human immunoglobulin G1 H chain that binds Plasmodium falciparum-infected erythrocytes. This receptor-based immunoadhesin is an effective and specific inhibitor of P. falciparum-infected erythrocyte adhesion to ICAM-1-bearing surfaces, but does not inhibit leukocyte function antigen 1 (LFA-1) interaction with ICAM-1. Furthermore, the immunoadhesin promotes phagocytosis and destruction of parasitized erythrocytes by human monocytes. Each of these modes of action has potential for the therapy of malaria.

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页码：1471 / 1476

页数：6

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