CHROMOSOMAL LOCATION OF HUMAN T-CELL RECEPTOR GENE TI-BETA

被引：47

作者：

BARKER, PE

RUDDLE, FH

ROYER, HD

ACUTO, O

REINHERZ, EL

机构：

[1] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR IMMUNOL,BOSTON,MA 02115

来源：

SCIENCE | 1984年 / 226卷 / 4672期

关键词：

D O I：

10.1126/science.6435246

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A complementary DNA probe corresponding to the β-chain gene of T i, the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the Tiβ gene was determined with the complementary DNA by screening a series of 12 cell hybrid (mouse x human) DNA's containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human Tiβ gene resides on chromosome 7 and is thus not linked to the immunoglobulin loci or to the major histocompatibility locus in humans.

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页码：348 / 349

页数：2

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