EXPRESSION OF ODORANT RECEPTORS IN SPATIALLY RESTRICTED SUBSETS OF CHEMOSENSORY NEURONS

被引：158

作者：

STROTMANN, J ^{[1
]}

WANNER, I ^{[1
]}

KRIEGER, J ^{[1
]}

RAMING, K ^{[1
]}

BREER, H ^{[1
]}

机构：

[1] UNIV STUTTGART HOHENHEIM,INST ZOOPHYSIOL,W-7000 STUTTGART 70,GERMANY

来源：

NEUROREPORT | 1992年 / 3卷 / 12期

关键词：

OLFACTION; ODORANT RECEPTORS; EXPRESSION; INSITU HYBRIDIZATION; RAT;

D O I：

10.1097/00001756-199212000-00005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

FROM a rat olfactory library a cDNA clone (OR37) which is supposed to encode an odorant receptor protein has been isolated and characterized. Specific antisense RNA and in situ hybridization techniques have been employed to monitor the olfactory epithelium for the distribution of olfactory neurones expressing the OR37-gene. The OR37-transcripts were detected only in a subset of receptor cells segregated in two restricted areas of the olfactory epithelium. The clusters of reactive cells appear symmetrically in both nasal cavities. Within a reactive region only a subset of the cells expressed the receptor. The segregation of neurones expressing a distinct receptor supports the notion that a spatial component may be involved in coding odour quality.

引用

页码：1053 / 1056

页数：4

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