MOLECULAR ANALYSIS OF MUTAGENESIS BY HIGH-LET RADIATION

被引：15

作者：

HEI, TK ^{[1
]}

ZHU, LX ^{[1
]}

VANNAIS, D ^{[1
]}

WALDREN, CA ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT RADIOL HLTH SCI,FT COLLINS,CO 80523

来源：

LIFE SCIENCES AND SPACE RESEARCH XXV(2): RADIATION BIOLOGY | 1994年 / 14卷 / 10期

关键词：

D O I：

10.1016/0273-1177(94)90488-X

中图分类号：

V [航空、航天];

学科分类号：

08 ; 0825 ;

摘要：

Mutation induction by high linear energy transfer [LET] alpha particles and gamma-rays was scored in the human hamster hybrid [A(L)] cells. Southern blotting technique was used to analyse the molecular changes in the DNA from both the HGPRT(-) and S1(-) mutants. Dose dependent mutagenesis in the A(L) cells irradiated with the charged particles was higher by almost 20 fold at the S1 than the corresponding HGPRT locus. Southern analysis of the mutants induced by the high LET particles showed mostly multilocus deletion at both the HGPRT and S1 genes.

引用

页码：355 / 361

页数：7

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