RULES FOR ALPHA-HELIX TERMINATION BY GLYCINE

被引：276

作者：

AURORA, R ^{[1
]}

SRINIVASAN, R ^{[1
]}

ROSE, GD ^{[1
]}

机构：

[1] WASHINGTON UNIV, SCH MED, DEPT BIOCHEM & MOLEC BIOPHYS, ST LOUIS, MO 63110 USA

来源：

SCIENCE | 1994年 / 264卷 / 5162期

关键词：

D O I：

10.1126/science.8178170

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A predictive rule for protein folding is presented that involves two recurrent glycine-based motifs that cap the carboxyl termini of cr. helices. In proteins, helices that terminated in glycine residues were found predominantly in one of these two motifs. These glycine structures had a characteristic pattern of polar and apolar residues. Visual inspection of known helical sequences was sufficient to distinguish the two motifs from each other and from internal glycines that fail to terminate helices. These glycine motifs-in which the local sequence selects between available structures-represent an example of a stereochemical rule for protein folding.

引用

页码：1126 / 1130

页数：5

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