ON THE IDENTIFICATION OF CEREBRAL METABOLITES IN LOCALIZED H-1-NMR SPECTRA OF HUMAN BRAIN INVIVO

被引：158

作者：

MICHAELIS, T ^{[1
]}

MERBOLDT, KD ^{[1
]}

HANICKE, W ^{[1
]}

GYNGELL, ML ^{[1
]}

BRUHN, H ^{[1
]}

FRAHM, J ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM,POSTFACH 2841,W-3400 GOTTINGEN,GERMANY

来源：

NMR IN BIOMEDICINE | 1991年 / 4卷 / 02期

关键词：

D O I：

10.1002/nbm.1940040211

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Localized H-1 NMR spectra of human brain in vivo are affected by signal overlap, strong spin-spin coupling, and complex J modulation, and therefore differ considerably from those obtained at higher magnetic fields. This paper deals with the assignment of H-1 NMR resonances of cerebral metabolites under the experimental conditions used for human investigations. Conventional 7.0-T FID spectra and 2.0 T localized, short echo time STEAM spectra (TE = 20 ms) of aqueous metabolite solutions are compared to in vivo brain spectra of human volunteers and patients. In addition to singlet resonances from N-acetyl aspartate (NAA), creatines, and cholines, short echo time STEAM spectra exhibit multiplets due to the NAA aspartyl group, glutamate, taurine, and myo-inositol. Enhanced levels of cerebral glutamine are detected in patients with liver cirrhosis. For the first time elevated levels of brain glucose are observed in patients with diabetes mellitus.

引用

页码：90 / 98

页数：9

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