THE INDUCTION OF CORTICOSTEROID ACTIONS ON MEMBRANE-PROPERTIES OF HIPPOCAMPAL CA1 NEURONS REQUIRES PROTEIN-SYNTHESIS

被引：62

作者：

KARST, H ^{[1
]}

JOELS, M ^{[1
]}

机构：

[1] STATE UNIV UTRECHT,INST MOLEC BIOL,UTRECHT,NETHERLANDS

来源：

NEUROSCIENCE LETTERS | 1991年 / 130卷 / 01期

关键词：

CORTICOSTERONE; MINERALOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR; HIPPOCAMPUS; CA1; CYCLOHEXIMIDE; ELECTROPHYSIOLOGY;

D O I：

10.1016/0304-3940(91)90219-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Corticosterone can affect electrical properties of CA1 pyramidal neurons via binding to two corticoid receptor types, the mineralocorticoid (MR) and glucocorticoid receptor (GR). Previously we have shown that MR-activation leads to attenuation of serotonin (5-HT)-induced membrane hyperpolarization, while GR-activation induces an increase in the amplitude of the afterhyperpolarization (AHP) following a short current pulse. In this study we show that the MR- and GR-mediated changes of the membrane properties are prevented in the presence of the protein synthesis inhibitor cycloheximide, thus suggesting a genomic action of the steroids.

引用

页码：27 / 31

页数：5

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