REDUCTION OF ADRENOCHROME BY RAT-LIVER AND BRAIN DT-DIAPHORASE

被引：15

作者：

BINDOLI, A ^{[1
]}

RIGOBELLO, MP ^{[1
]}

GALZIGNA, L ^{[1
]}

机构：

[1] UNIV PADUA,CTR STUDIO FISIOL MITOCONDRIALE,I-35131 PADUA,ITALY

来源：

FREE RADICAL RESEARCH COMMUNICATIONS | 1990年 / 8卷 / 4-6期

关键词：

Adrenochrome; DT-diaphorase; Quinones;

D O I：

10.3109/10715769009053362

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liver and brain exhibit DT-diaphorase activity with adrenochrome as a substrate; the latter is an o-quinone derived from the autoxidation of adrenaline exhibiting neurotoxic and cardiotoxic properties. The reaction is strongly inhibited by dicoumarol. a classical inhibitor of DT-diaphorase. DT-diaphorase-reduced adrenochrome undergoes autoxidation as shown by the oxygen uptake occurring during the reaction It is proposed that, physiologically, DT-diaphorase might exert a protective role by maintaining adrenochrome in its reduced, non-toxic form © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：295 / 298

页数：4

共 13 条

[1] TOXICITY OF AMINOCHROMES [J].

BINDOLI, A ;

RIGOBELLO, MP ;

GALZIGNA, L .

TOXICOLOGY LETTERS, 1989, 48 (01) :3-20

[2]

Bindoli A., 1988, FREE RADICALS CHEM P, P293

[3] PULSE-RADIOLYTIC INVESTIGATIONS OF CATECHOLS AND CATECHOLAMINES .1. ADRENALINE AND ADRENOCHROME [J].

BORS, W ;

SARAN, M ;

MICHEL, C ;

LENGFELDER, E ;

FUCHS, C ;

SPOTTL, R .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1975, 28 (04) :353-371

[4] EFFECT OF SUPEROXIDE-DISMUTASE ON THE AUTOXIDATION OF VARIOUS HYDROQUINONES - A POSSIBLE ROLE OF SUPEROXIDE-DISMUTASE AS A SUPEROXIDE SEMIQUINONE OXIDOREDUCTASE [J].

CADENAS, E ;

MIRA, D ;

BRUNMARK, A ;

LIND, C ;

SEGURAAGUILAR, J ;

ERNSTER, L .

FREE RADICAL BIOLOGY AND MEDICINE, 1988, 5 (02) :71-79

[5]

ERNSTER L, 1987, CHEM SCRIPTA, V27A, P1

[6]

ERNSTER L, 1967, METHOD ENZYMOL, V10, P309, DOI DOI 10.1016/0076-6879(67)10059-1

[7]

Estabrook R., 1967, METHOD ENZYMOL, V10, P41, DOI DOI 10.1016/0076-6879(67)10010-4

[8] PURIFICATION AND SOME PROPERTIES OF A BRAIN DIAPHORASE [J].

GIUDITTA, A ;

STRECKER, HJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1960, 2 (03) :159-163

[9]

HEACOCK RA, 1971, B CHIM THER, V6, P300

[10] DT-DIAPHORASE AS A QUINONE REDUCTASE - A CELLULAR CONTROL DEVICE AGAINST SEMI-QUINONE AND SUPEROXIDE RADICAL FORMATION [J].

LIND, C ;

HOCHSTEIN, P ;

ERNSTER, L .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1982, 216 (01) :178-185

← 1 2 →