CYTOPROTECTION AGAINST NEUTROPHIL DERIVED HYPOCHLOROUS ACID - A POTENTIAL MECHANISM FOR THE THERAPEUTIC ACTION OF 5-AMINOSALICYLIC ACID IN ULCERATIVE-COLITIS

被引：69

作者：

DALLEGRI, F ^{[1
]}

OTTONELLO, L ^{[1
]}

BALLESTRERO, A ^{[1
]}

BOGLIOLO, F ^{[1
]}

FERRANDO, F ^{[1
]}

PATRONE, F ^{[1
]}

机构：

[1] UNIV GENOA,SCH MED,MED CLIN 1,I-16126 GENOA,ITALY

来源：

GUT | 1990年 / 31卷 / 02期

关键词：

D O I：

10.1136/gut.31.2.184

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The aim of the present study was to investigate the effects of 5-aminosalicylic acid (5-ASA) on the cell injury mediated by activated neutrophils. We used a system constituted of neutrophils, triggered with phorbol myristate acetate, and 51Cr-labelled Daudi cells as targets. The results show that 5-ASA is capable of efficiently preventing neutrophil-mediated lysis. 5-ASA was up to 10-fold more effective than taurine, which acts as an hypochlorous acid scavenger. Moreover, 5-ASA was found to compete with taurine for the neutrophil derived hypochlorous acid. The results are consistent with the conclusion that 5-ASA is capable of limiting the neutrophil mediated cell damage by scavenging the generated hypochlorous acid. This may represent a potential mechanism for the therapeutic action of 5-ASA in ulcerative colitis.

引用

页码：184 / 186

页数：3

共 17 条

[1] THE SCAVENGING OF OXIDANTS BY SULFASALAZINE AND ITS METABOLITES - A POSSIBLE CONTRIBUTION TO THEIR ANTIINFLAMMATORY EFFECTS [J].