STRUCTURAL ALERTS TO GENOTOXICITY - THE INTERACTION OF HUMAN AND ARTIFICIAL-INTELLIGENCE

被引：38

作者：

ROSENKRANZ, HS ^{[1
]}

KLOPMAN, G ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106

来源：

MUTAGENESIS | 1990年 / 5卷 / 04期

关键词：

D O I：

10.1093/mutage/5.4.333

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The assignments of 'structural alerts' by Ashby and associates as predictors of genotoxic carcinogenicity were used as the entries for CASE, an artificial intelligence-based structure-activity relational method. CASE, using this human intelligence-based information, was able to derive structural determinants that duplicate the informational content of the structural alerts (sensitivity, 0.974; specificity, 0.948). The CASE-predicted alerts performed as well as the results of the Salmonella mutagenicity assay or the direct application of structural alerts in predicting carcinogens. © 1990 Oxford University Press.

引用

页码：333 / 361

页数：29

共 59 条

[1] METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST [J].

AMES, BN ;

MCCANN, J ;

YAMASAKI, E .

MUTATION RESEARCH, 1975, 31 (06) :347-363

[2] COMPUTER-ASSISTED SHORT-TERM TEST BATTERY DESIGN - SOME QUESTIONS [J].

ASHBY, J .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1988, 11 (04) :443-448

[3] THE SEPARATE IDENTITIES OF GENOTOXIC AND NON-GENOTOXIC CARCINOGENS [J].

ASHBY, J .

MUTAGENESIS, 1988, 3 (04) :365-366

[4] ARE NON-MUTAGENIC CARCINOGENS MERELY CRYPTOMUTAGENS [J].

ASHBY, J .

MUTATION RESEARCH, 1989, 216 (05) :267-267

[5] CLASSIFICATION ACCORDING TO CHEMICAL-STRUCTURE, MUTAGENICITY TO SALMONELLA AND LEVEL OF CARCINOGENICITY OF A FURTHER 42 CHEMICALS TESTED FOR CARCINOGENICITY BY THE UNITED-STATES NATIONAL TOXICOLOGY PROGRAM [J].

ASHBY, J ;

TENNANT, RW ;

ZEIGER, E ;

STASIEWICZ, S .

MUTATION RESEARCH, 1989, 223 (02) :73-103

[6] REFLECTIONS ON THE DECLINING ABILITY OF THE SALMONELLA ASSAY TO DETECT RODENT CARCINOGENS AS POSITIVE [J].

ASHBY, J ;

PURCHASE, IFH .

MUTATION RESEARCH, 1988, 205 (1-4) :51-58

[7] FUNDAMENTAL STRUCTURAL ALERTS TO POTENTIAL CARCINOGENICITY OR NONCARCINOGENICITY [J].

ASHBY, J .

ENVIRONMENTAL MUTAGENESIS, 1985, 7 (06) :919-921

[8] CHEMICAL-STRUCTURE, SALMONELLA MUTAGENICITY AND EXTENT OF CARCINOGENICITY AS INDICATORS OF GENOTOXIC CARCINOGENESIS AMONG 222 CHEMICALS TESTED IN RODENTS BY THE UNITED-STATES NCI/NTP [J].

ASHBY, J ;

TENNANT, RW .

MUTATION RESEARCH, 1988, 204 (01) :17-115

[9] STRUCTURAL-ANALYSIS AS A MEANS OF PREDICTING CARCINOGENIC POTENTIAL [J].

ASHBY, J .

BRITISH JOURNAL OF CANCER, 1978, 37 (06) :904-923

[10] INVITRO EVALUATION OF SOME DERIVATIVES OF CARCINOGEN BUTTER YELLOW - IMPLICATIONS FOR ENVIRONMENTAL SCREENING [J].

ASHBY, J ;

STYLES, JA ;

PATON, D .

BRITISH JOURNAL OF CANCER, 1978, 38 (01) :34-50

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