INTERLEUKIN-6 AND ITS RECEPTOR - A PARADIGM FOR CYTOKINES

被引：861

作者：

KISHIMOTO, T ^{[1
]}

AKIRA, S ^{[1
]}

TAGA, T ^{[1
]}

机构：

[1] OSAKA UNIV, INST MOLEC & CELLULAR BIOL, SUITA, OSAKA 565, JAPAN

来源：

SCIENCE | 1992年 / 258卷 / 5082期

关键词：

D O I：

10.1126/science.1411569

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many cytokines and cytokine receptors involved in the regulation of hematopoiesis, immune responses, and inflammation have been identified and characterized at the molecular level. Several characteristic features of cytokines, such as pleiotropy and redundancy, are now more clearly understood on the basis of their molecular structures. Accumulating evidence has demonstrated an intimate link between cytokines and various diseases such as allergy, autoimmune diseases, and cancer. The pathogenesis of these diseases and therapies to treat them will be discussed based on insights derived from cytokine research.

引用

页码：593 / 597

页数：5

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