GANGLIOSIDE GM1 REDUCES FETAL ALCOHOL EFFECTS IN RAT PUPS EXPOSED TO ETHANOL IN-UTERO

被引：21

作者：

HUNGUND, BL ^{[1
]}

ROSS, DC ^{[1
]}

GOKHALE, VS ^{[1
]}

机构：

[1] COLUMBIA UNIV,COLL PHYS & SURG,DEPT PSYCHIAT,NEW YORK,NY 10032

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1994年 / 18卷 / 05期

关键词：

FETAL ALCOHOL EFFECTS; GESTATIONAL DAYS; GANGLIOSIDE GM1;

D O I：

10.1111/j.1530-0277.1994.tb00113.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

We have investigated the effect of in utero ethanol exposure and ganglioside GM1 pretreatment on the endogenous ganglioside profile of the rat fetal brain. Prenatal ethanol exposure on gestation day (GD)7 and GD8 and/or GD13 end GD14 leads to a very significant increase in the ganglioside GM1 content in at least 50% of the pup brains when assayed on GD20. This treatment protocol also results in significant decrease in the content of polysialogangliosides GD1a, GT1b, and GQ1b. GM1 treatment of pregnant dams before ethanol administration prevented this alteration in pup brain ganglioside profile. Ganglioside GM1 pretreatment appears to block the cellular membrane changes associated with fetal alcohol effects and thereby minimizes alterations in brain maturation and associated behavioral dysfunction.

引用

页码：1248 / 1251

页数：4

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