DELETION MAPPING OF H-Y-ANTIGEN TO THE LONG ARM OF THE HUMAN Y-CHROMOSOME

被引：21

作者：

CANTRELL, MA

BOGAN, JS

SIMPSON, E

BICKNELL, JN

GOULMY, E

CHANDLER, P

PAGON, RA

WALKER, DC

THULINE, HC

GRAHAM, JM

DELACHAPELLE, A

PAGE, DC

DISTECHE, CM

机构：

[1] UNIV WASHINGTON, DEPT PATHOL SM-30, SEATTLE, WA 98195 USA

[2] STATE WASHINGTON DEPT SOCIAL & HLTH SCI, GENET SERV SECT, SEATTLE, WA 98155 USA

[3] UNIV CALIF LOS ANGELES, CEDARS SINAI MED CTR, CTR MED GENET BIRTH DEFECTS, AHMANSON PEDIAT CTR, LOS ANGELES, CA 90048 USA

[4] UNIV HELSINKI, DEPT MED GENET, SF-00290 HELSINKI 29, FINLAND

[5] MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA

[6] WHITEHEAD INST, HOWARD HUGHES RES LABS, CAMBRIDGE, MA 02142 USA

[7] CLIN RES CTR, TRANSPLANTAT BIOL SECT, HARROW HA1 3UJ, MIDDX, ENGLAND

[8] UNIV HOSP LEIDEN, AZL, DEPT IMMUNOHAEMATOL, 2300 RC LEIDEN, NETHERLANDS

[9] UNIV WASHINGTON, DEPT PEDIAT & MED, SEATTLE, WA 98195 USA

[10] UNIV HOSP LEIDEN, AZL, BLOOD BANK, 2300 RC LEIDEN, NETHERLANDS

来源：

GENOMICS | 1992年 / 13卷 / 04期

基金：

美国国家卫生研究院; 芬兰科学院;

关键词：

D O I：

10.1016/0888-7543(92)90043-R

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A gene encoding or controlling the expression of the H-Y transplantation antigen was previously mapped to the human Y chromosome. We now report the sublocalization of this gene on the long arm of the human Y chromosome. Eight patients with Y-chromosomal abnormalities were examined with a series of existing and new DNA markers for the Y chromosome. The resulting deletion map was correlated with H-Y antigen expression. We conclude that the H-Y antigen gene maps to a portion of deletion interval 6 that is identified by specific DNA markers. © 1992.

引用

页码：1255 / 1260

页数：6

共 30 条

[1] REGIONAL ASSIGNMENT OF Y-LINKED DNA PROBES BY DELETION MAPPING AND THEIR HOMOLOGY WITH X-CHROMOSOME AND AUTOSOMAL SEQUENCES [J].