THE FERRIC IRON-BINDING PROTEIN OF PATHOGENIC NEISSERIA SPP FUNCTIONS AS A PERIPLASMIC TRANSPORT PROTEIN IN IRON ACQUISITION FROM HUMAN TRANSFERRIN

被引:104
作者
CHEN, CY [1 ]
BERISH, SA [1 ]
MORSE, SA [1 ]
MIETZNER, TA [1 ]
机构
[1] UNIV PITTSBURGH,SCH MED,DEPT MOLEC GENET & BIOCHEM,PITTSBURGH,PA 15261
关键词
D O I
10.1111/j.1365-2958.1993.tb01957.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The ferric iron-binding protein (Fbp) expressed by pathogenic Neisseria spp. has been proposed to play a central role in the high-affinity acquisition of iron from human transferrin. The results of this investigation provide evidence that Fbp participates in this process as a functional analogue of a Gram-negative periplasmic-binding protein component, which operates as a part of a general active transport process for the receptor-mediated, high-affinity transport of iron from human transferrin. Known properties of Fbp are correlated with those of other well-characterized periplasmic-binding proteins, including structural features and the reversible binding of ligand. Predictive of a periplasmic-binding protein, which functions in the high-affinity acquisition of iron, is that Fbp is a transient participant in the process of iron acquisition from human transferrin. Evidence for this is demonstrated by results of pulse-chase experiments. Taken together, the data described here and elsewhere suggest that pathogenic Neisseria spp. use a periplasmic-binding protein-mediated active transport mechanism for the acquisition of iron from human transferrin.
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页码:311 / 318
页数:8
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