GLIAL SWELLING FOLLOWING HUMAN CEREBRAL CONTUSION - AN ULTRASTRUCTURAL-STUDY

被引：155

作者：

BULLOCK, R

MAXWELL, WL

GRAHAM, DI

TEASDALE, GM

ADAMS, JH

机构：

[1] Department of Neurosurgery, Inst. of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, Govan Road

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1991年 / 54卷 / 05期

关键词：

D O I：

10.1136/jnnp.54.5.427

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The ultrastructural features of cerebral contusion seen three hours to 11 days after head injury were studied in 18 patients undergoing surgery. Massive astrocytic swelling ("cytotoxic" oedema) was seen three hours to three days after injury, maximal in perivascular foot processes, and compressing some of the underlying capillaries. The tight junctions were not disrupted. Neuronal damage was most marked three to 11 days after injury. The pathophysiological mechanisms leading to oedema formation and neuronal degeneration are discussed.

引用

页码：427 / 434

页数：8

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