A T(H)1-]T(H)2 SWITCH IS A CRITICAL STEP IN THE ETIOLOGY OF HIV-INFECTION

被引：1325

作者：

CLERICI, M

SHEARER, GM

机构：

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 03期

关键词：

D O I：

10.1016/0167-5699(93)90208-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This viewpoint proposes that an imbalance in the T(H)1-type and T(H)2-type responses contributes to the immune dysregulation associated with HIV infection, and that resistance to HIV infection and/or progression to AIDS is dependent on a T(H)1 > T(H)2 dominance. This hypothesis is based on the authors' findings that: (1) progression to AIDS is characterized by loss of IL-2- and IFN-gamma production concomitant with increases in IL-4 and IL-10; and (2) many seronegative, HIV-exposed individuals generate strong T(H)1-type responses to HIV antigens.

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页码：107 / 110

页数：4

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