GLUTAMATE INDUCES CALCIUM WAVES IN CULTURED ASTROCYTES - LONG-RANGE GLIAL SIGNALING

被引：1489

作者：

CORNELLBELL, AH ^{[1
]}

FINKBEINER, SM ^{[1
]}

COOPER, MS ^{[1
]}

SMITH, SJ ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, NEW HAVEN, CT 06510 USA

来源：

SCIENCE | 1990年 / 247卷 / 4941期

关键词：

D O I：

10.1126/science.1967852

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The finding that astrocytes possess glutamate-sensitive ion channels hinted at a previously unrecognized signaling role for these cells. Now it is reported that cultured hippocampal astrocytes can respond to glutamate with a prompt and oscillatory elevation of cytoplasmic free calcium, visible through use of the fluorescent calcium indicator fluo-3. Two types of glutamate receptor-one preferring quisqualate and releasing calcium from intracellular stores and the other preferring kainate and promoting surface-membrane calcium influx-appear to be involved. Moreover, glutamate-induced increases in cytoplasmic free calcium frequently propagate as waves within the cytoplasm of individual astrocytes and between adjacent astrocytes in confluent cultures. These propagating waves of calcium suggest that networks of astrocytes may constitute a long-range signaling system within the brain.

引用

页码：470 / 473

页数：4

共 36 条

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