THE GAL4 SYSTEM AS A TOOL FOR UNRAVELING THE MYSTERIES OF THE DROSOPHILA NERVOUS-SYSTEM

被引：100

作者：

BRAND, AH ^{[1
]}

DORMAND, EL ^{[1
]}

机构：

[1] UNIV CAMBRIDGE, DEPT GENET, CAMBRIDGE CB2 1QR, ENGLAND

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1995年 / 5卷 / 05期

关键词：

D O I：

10.1016/0959-4388(95)80061-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The GAL4 system is a method for directed gene expression that allows genes to be expressed ectopically in numerous cell- or tissue-specific patterns. The technique is being exploited to study the Drosophila melanogaster nervous system at all stages of development, from the embryo to the adult. The GAL4 system is being used to target the expression of novel marker genes in living animals to label cells, or subcellular structures. Directed expression oi toxin genes can be used as a method for targeted cell ablation to study the role of cell-cell interactions in development. Ectopic expression helps to elucidate the function of different genes in cell fate determination and differentiation, and is helping to define the regions of the brain involved in sexual behaviour.

引用

页码：572 / 578

页数：7

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