THE INWARD RECTIFIER POTASSIUM CHANNEL FAMILY

被引:410
作者
DOUPNIK, CA
DAVIDSON, N
LESTER, HA
机构
[1] Division of Biology 156-29, California Institute of Technology, Pasadena
关键词
D O I
10.1016/0959-4388(95)80038-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent cloning of a family of genes encoding inwardly rectifying K+ channels has provided the opportunity to explain some venerable problems in membrane biology. An expanding number of novel inwardly rectifying K+ channel clones has revealed multiple channel subfamilies that have specialized roles in cell function. The molecular determinants of inward rectification have been largely elucidated with the discovery of endogenous polyamines that act as voltage-dependent intracellular channel blockers, and with the identification of a critical site in the channel that mediates high-affinity block by both polyamines and Mg2+.
引用
收藏
页码:268 / 277
页数:10
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