EXPRESSION OF 120 KILODALTON PROTEIN AND CYTOTOXICITY IN HELICOBACTER-PYLORI

被引：100

作者：

CRABTREE, JE

FIGURA, N

TAYLOR, JD

BUGNOLI, M

ARMELLINI, D

TOMPKINS, DS

机构：

[1] BRADFORD ROYAL INFIRM,DEPT MICROBIOL,BRADFORD,ENGLAND

[2] UNIV SIENA,IST MALATTIE INFETT,I-53100 SIENNA,ITALY

[3] SCLAVO RES CTR,SIENNA,ITALY

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1992年 / 45卷 / 08期

关键词：

D O I：

10.1136/jcp.45.8.733

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Antral biopsy culture supernatants from 14 subjects with chronic gastritis, known to have IgA antibodies to the 120 kilodalton protein, showed positive recognition of this antigen in western blots against a cytotoxin positive strain of Helicobacter pylori but gave negative reactions with two cytotoxin negative strains. Control immunoblots with culture supernatants from 13 non-responders to the protein were all negative. This indicates a direct association between expression of the 120 kilodalton protein in H pylori strains and cytotoxicity.

引用

页码：733 / 734

页数：2

共 8 条

[1]

APEL I, 1988, ZBL BAKT-INT J MED M, V268, P271

[2] CHARACTERIZATION OF AND HUMAN SEROLOGIC RESPONSE TO PROTEINS IN HELICOBACTER-PYLORI BROTH CULTURE SUPERNATANTS WITH VACUOLIZING CYTOTOXIN ACTIVITY [J].