INFECTIVITY OF TITERED DOSES OF SIMIAN IMMUNODEFICIENCY VIRUS CLONE E11S INOCULATED INTRAVENOUSLY INTO RHESUS MACAQUES (MACACA-MULATTA)

被引：11

作者：

BENVENISTE, RE

ROODMAN, ST

HILL, RW

KNOTT, WB

RIBAS, JL

LEWIS, MG

EDDY, GA

机构：

[1] ST LOUIS UNIV,SCH MED,ST LOUIS,MO 63104

[2] NCI,FCRDC,PROGRAM RESOURCES INC,DYNCERP,FREDERICK,MD 21701

[3] HENRY M JACKSON FDN,RES LAB,ROCKVILLE,MD

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1994年 / 23卷 / 2-3期

关键词：

AIDS; VACCINES; ANIMAL INFECTIOUS DOSE; SIV;

D O I：

10.1111/j.1600-0684.1994.tb00106.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The macaque infectious dose (MID) of a single-cell clone of simian immunodeficiency virus isolated from a pig-tailed macaque (SIV/Mne clone E11S) was determined in rhesus macaques (Macaca mulatta). Twenty-one macaques were inoculated with 10-fold dilutions of the virus stock (three or four animals per dose). The virologic and clinical status of these animals was monitored for 26 weeks. The 25% MID (MID25) occurred at a 10(5)-fold dilution of the viral stock.

引用

页码：83 / 88

页数：6

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