PROPOSED ACQUISITION OF AN ANIMAL PROTEIN DOMAIN BY BACTERIA

被引：222

作者：

BORK, P

DOOLITTLE, RF

机构：

[1] MAX DELBRUCK CTR MOLEC MED, W-1115 BERLIN, GERMANY

[2] UNIV CALIF SAN DIEGO, CTR MOLEC GENET, LA JOLLA, CA 92093 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 19期

关键词：

HORIZONTAL GENE TRANSFER; MOBILE DOMAINS; FIBRONECTIN TYPE-III;

D O I：

10.1073/pnas.89.19.8990

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A systematic screen of a protein sequence data base confirms that the fibronectin type III (Fn3) domain is widely distributed among animal proteins and occurs also in several bacterial carbohydrate-splitting enzymes. The motif has yet to be identified in proteins from plants or fungi. All indications are that the bacterial sequences are much too similar to the animal type to be the result of conventional vertical descent. Rather, it is likely that the bacterial units were initially acquired from an animal source and are being spread further by horizontal transfers between distantly related bacteria.

引用

页码：8990 / 8994

页数：5

共 36 条

[1] THE SWISS-PROT PROTEIN-SEQUENCE DATA-BANK [J].