METABOTROPIC GLUTAMATE RECEPTOR-INDUCED DISINHIBITION IS MEDIATED BY REDUCED TRANSMISSION AT EXCITATORY SYNAPSES ONTO INTERNEURONS AND INHIBITORY SYNAPSES ONTO PYRAMIDAL CELLS

被引：59

作者：

DESAI, MA

MCBAIN, CJ

KAUER, JA

CONN, PJ

机构：

[1] EMORY UNIV,SCH MED,DEPT PHARMACOL,ATLANTA,GA 30322

[2] DUKE UNIV,MED CTR,DEPT NEUROBIOL,DURHAM,NC 27710

来源：

NEUROSCIENCE LETTERS | 1994年 / 181卷 / 1-2期

关键词：

METABOTROPIC GLUTAMATE RECEPTOR; SYNAPTIC INHIBITION; ACPD; INHIBITORY POSTSYNAPTIC POTENTIAL; INTERNEURON; HIPPOCAMPUS;

D O I：

10.1016/0304-3940(94)90564-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies suggest that activation of metabotropic glutamate receptors (mGluRs) reduces GABA-mediated synaptic inhibition in area CA1 of the hippocampus. However, the mechanisms involved in this disinhibition are not known. We report that mGluR activation reduces both the GABA(A) and GABA(B) receptor-mediated components of evoked inhibitory postsynaptic potentials (IPSPs) by reducing transmission at excitatory synapses onto inhibitory interneurons and inhibitory synapses onto CA1 pyramidal cells.

引用

页码：78 / 82

页数：5

共 22 条

[1] AGONISTS AT METABOTROPIC GLUTAMATE RECEPTORS PRESYNAPTICALLY INHIBIT EPSCS IN NEONATAL RAT HIPPOCAMPUS [J].