METABOTROPIC GLUTAMATE RECEPTORS CONTRIBUTE TO THE INDUCTION OF LONG-TERM DEPRESSION IN THE CA1 REGION OF THE HIPPOCAMPUS

被引：121

作者：

BASHIR, ZI ^{[1
]}

JANE, DE ^{[1
]}

SUNTER, DC ^{[1
]}

WATKINS, JC ^{[1
]}

COLLINGRIDGE, GL ^{[1
]}

机构：

[1] UNIV BRISTOL,SCH MED SCI,DEPT PHARMACOL,BRISTOL BS8 1TD,AVON,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 239卷 / 1-3期

关键词：

LONG-TERM DEPRESSION; LONG-TERM POTENTIATION; GLUTAMATE METABOTROPIC RECEPTORS; ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE;

D O I：

10.1016/0014-2999(93)91009-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Long-term depression of synaptic transmission was induced following the prior induction of long-term potentiation in the CA1 region of rat hippocampal slices. We show that the induction of this form of synaptic depression can be prevented by (+)-alpha-methyl-4-carboxyphenylglycine, a selective antagonist of metabotropic glutamate receptors.

引用

页码：265 / 266

页数：2

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