A LOCALIZATION STUDY OF THE CYTOCHROME P-45021-LINKED MONOOXYGENASE SYSTEM IN ADULT-RAT BRAIN

被引：19

作者：

IWAHASHI, K

KAWAI, Y

SUWAKI, H

HOSOKAWA, K

ICHIKAWA, Y

机构：

[1] KAGAWA MED SCH,DEPT BIOCHEM,KAGAWA 76107,JAPAN

[2] KAGAWA MED SCH,DEPT ANAT,KAGAWA 76107,JAPAN

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1993年 / 44卷 / 02期

关键词：

D O I：

10.1016/0960-0760(93)90024-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immunohistochemical studies were performed to investigate the localization of the cytochrome P-450(21)-linked monooxygenase system in rat brain using a specific antibody against bovine adrenal cytochrome P-450(21) (P-450XXIA1), which was purified electrophoretically as a single protein band and with a heme content of 18.0 nmol/mg protein from adrenocortical microsomes. The cytochrome P-450(21) was found to be mainly localized in the tractus reticulothalamicus and other ascending fibers in adult rat brains. This finding indicated that deoxycorticosterone or its derivatives could be implicated in the regulation of consciousness and the induction of an anesthetic effect.

引用

页码：163 / 169

页数：7

共 17 条

[1] IMMUNOCYTOCHEMICAL LOCALIZATION OF AROMATASE IN THE BRAIN [J].