MUTAGENESIS BY 8-OXOGUANINE - AN ENEMY WITHIN

被引：741

作者：

GROLLMAN, AP

MORIYA, M

机构：

[1] Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook

来源：

TRENDS IN GENETICS | 1993年 / 9卷 / 07期

关键词：

D O I：

10.1016/0168-9525(93)90089-Z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The presence of reactive oxygen species in cells ensures that the oxidatively damaged base 8-oxoguanine will be generated at high frequency in the DNA of all living organisms. DNA damage threatens genomic integrity: enzymes have evolved that protect prokaryotes and eukaryotes from the mutagenic effect of this ubiquitous lesion.

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页码：246 / 249

页数：4

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