PHARMACOGENETICS OF ACUTE AZATHIOPRINE TOXICITY - RELATIONSHIP TO THIOPURINE METHYLTRANSFERASE GENETIC-POLYMORPHISM

被引:476
作者
LENNARD, L [1 ]
VANLOON, JA [1 ]
WEINSHILBOUM, RM [1 ]
机构
[1] MAYO CLIN & MAYO FDN,DEPT PHARMACOL,CLIN PHARMACOL UNIT,ROCHESTER,MN 55905
关键词
D O I
10.1038/clpt.1989.119
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:149 / 154
页数:6
相关论文
共 23 条
[1]   MACROCYTOSIS AND PURE RBC ANEMIA CAUSED BY AZATHIOPRINE [J].
DECLERCK, YA ;
ETTENGER, RB ;
ORTEGA, JA ;
PENNISI, AJ .
AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1980, 134 (04) :377-379
[2]  
GOADSBY PJ, 1986, LANCET, V2, P869
[3]   VARIABILITY IN CAFFEINE METABOLISM [J].
GRANT, DM ;
TANG, BK ;
KALOW, W .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1983, 33 (05) :591-602
[4]   EFFECT OF ALLOPURINOL ON CAFFEINE DISPOSITION IN MAN [J].
GRANT, DM ;
TANG, BK ;
CAMPBELL, ME ;
KALOW, W .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 21 (04) :454-458
[5]   6-MERCAPTOPURINE - APPARENT LACK OF RELATION BETWEEN PRESCRIBED DOSE AND BIOLOGICAL EFFECT IN CHILDREN WITH LEUKEMIA [J].
HERBER, S ;
LENNARD, L ;
LILLEYMAN, JS ;
MADDOCKS, J .
BRITISH JOURNAL OF CANCER, 1982, 46 (01) :138-141
[6]   PANCYTOPENIA RELATED TO AZATHIOPRINE IN RHEUMATOID-ARTHRITIS [J].
JEURISSEN, MEC ;
BOERBOOMS, AMT ;
VANDEPUTTE, LBA .
ANNALS OF THE RHEUMATIC DISEASES, 1988, 47 (06) :503-505
[7]  
KVIEN TK, 1986, J RHEUMATOL, V13, P118
[8]   SEVERE MEGALOBLASTIC-ANEMIA ASSOCIATED WITH ABNORMAL AZATHIOPRINE METABOLISM [J].
LENNARD, L ;
MURPHY, MF ;
MADDOCKS, JL .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 17 (02) :171-172
[9]   THIOPURINE PHARMACOGENETICS IN LEUKEMIA - CORRELATION OF ERYTHROCYTE THIOPURINE METHYLTRANSFERASE ACTIVITY AND 6-THIOGUANINE NUCLEOTIDE CONCENTRATIONS [J].
LENNARD, L ;
VANLOON, JA ;
LILLEYMAN, JS ;
WEINSHILBOUM, RM .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1987, 41 (01) :18-25
[10]   AZATHIOPRINE METABOLISM IN KIDNEY-TRANSPLANT RECIPIENTS [J].
LENNARD, L ;
BROWN, CB ;
FOX, M ;
MADDOCKS, JL .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 18 (05) :693-700