TRANSLATIONAL CONTROL MEDIATED BY UA-RICH SEQUENCES

被引：50

作者：

KRUYS, V

BEUTLER, B

HUEZ, G

机构：

[1] UNIV LIBRE BRUXELLES,DEPT BIOL MOLEC,CHIM BIOL LAB,RUE CHEVAUX 67,B-1640 RHODE ST GENESE,BELGIUM

[2] UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED CTR,DALLAS,TX 75230

[3] UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,DALLAS,TX 75230

来源：

ENZYME | 1990年 / 44卷 / 1-4期

关键词：

3'-UNTRANSLATED REGION; MESSENGER RNA DEGRADATION; CYTOKINES; XENOPUS OOCYTES; MACROPHAGES; INTERFERON; TNF; GM-CSF;

D O I：

10.1159/000468757

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several messenger RNAs coding for cytokines, growth factors or oncoproteins contain a conserved UA-rich sequence in their 3' untranslated regions. This sequence, which is composed of several interspersed repeats of the octanucleotide UUAUUUAU, is a key element in the posttranscriptional regulation of these mRNAs. Previously shown to be involved in mRNA destabilization, these UA-rich elements can also strongly influence mRNA translation. A translation inhibition mediated by these sequences has indeed been observed in vitro as well as in frog oocyte or in somatic cells.

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页码：193 / 202

页数：10

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