TUMOR-NECROSIS-FACTOR REDUCES LIFE-SPAN OF HUMAN ENDOTHELIAL-CELLS INVITRO

被引：16

作者：

SHIMADA, Y

ITO, H

KAJI, K

FUKUDA, M

机构：

[1] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT ENDOCRINOL,ITABASHI KU,TOKYO 173,JAPAN

[2] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT BIOCHEM,ITABASHI KU,TOKYO 173,JAPAN

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1990年 / 55卷 / 03期

关键词：

Cellular aging; Endothelial cells; Tumor necrosis factor;

D O I：

10.1016/0047-6374(90)90152-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tumor necrosis factor (TNF) is known to regulate the proliferation and function of vascular endothelial cells (ECs). We have examined the effects of TNF on the growth and aging of human ECs of different origins and compared them with those in human normal diploid fibroblasts. The results obtained were as follows: (1) TNF reduces the growth rate and in vitro life span of ECs in both dose- and treatment length-dependent fashions; (2) ECs are significantly more sensitive to TNF than fibroblasts; and (3) the life span shortening effect of TNF on ECs increases as a function of in vitro cell age. These results suggest that the aging of ECs is modified by TNF exposure. © 1990.

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页码：245 / 254

页数：10

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