Comparative study of the roles of ACTH and β-endorphin in regulating conditioned reflex activity in the hedgehog

被引：7

作者：

Sollertinskaya T.N. ^{[1
]}

机构：

[1] Laboratory for Comparative Cerebellar Physiology, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg

来源：

Neuroscience and Behavioral Physiology | 1997年 / 27卷 / 6期

关键词：

ACTH; Conditioned reflex activity; Conditioned reflex traces; Limbic cortex; Neuropeptides; β-endorphin;

D O I：

10.1007/BF02461924

中图分类号：

学科分类号：

摘要：

Data on the relative effects of the neurohormone ACTH1-39 and the opioid peptide β-endorphin on conditioned reflex activity in the hedgehog are presented. It was demonstrated that administration of ACTH (30-50 μg/kg s.c.) led to facilitation of learning and strengthening of memory processes (conditioned reflex traces). ACTH promoted strengthening of movement, orientational-investigative, and intersignal activities, produced hyperalgesia, and blocked the effects of naloxone. Administration of β-endorphin (30-40 μg/kg s.c.) lengthened the latent periods of conditioned reflexes, produced a pronounced analgesic effect, and reduced movement and intersignal activities. The effects of β-endorphin were eliminated by dosage with naloxone. Administration of β-endorphin blocked the inhibitor effects of stimulation of the limbic cortex; doses of ACTH produced partial release of inhibitory effects. The differences between the effects of ACTH and β-endorphin on higher nervous activity are discussed, as are the possible mechanisms of these effects. ©1997 Plenum Publishing Corporation.

引用

页码：663 / 671

页数：8

共 22 条

[1]

Ashmarin I.P., Antonova L.V., Titov S.A., Possible mechanisms of the differently-directed actions of ACTH4-10 and its phenylalanine analog-containing isomer on behavior, Zh. Vyssh. Nerv. Deyat., 30, 6, pp. 1196-1203, (1980)

[2]

Ashmarin I.P., Kamenskii A.A., Shelokhov S.L., The action of adrenocorticotrophic hormone analog ACTH4-10 on learning in white rats in conditions of positive reinforcement, Dokl. Akad. Nauk SSSR, 240, 5, pp. 245-247

[3]

Vitvitskaya L.V., Bikvulatova L.S., Nikanrov S.I., Kruglikov R.I., The effect of neuropeptide ACTH4-7 on conditioned reflex activity and nucleic acid metabolism in the brains of Atlantic salmon fry, Dokl. Akad. Nauk SSSR, 292, 4, pp. 1002-1006, (1986)

[4]

Voronin L.G., Tsitolovskaya L.A., Improvement in the reproduction of a chain of conditioned reflexes developed in early ontogenesis of rats, mediated by ACTH4-10, Dokl. Akad. Nauk SSSR, 255, 6, pp. 1507-1509, (1980)

[5]

Karamyan A.I., Sollertinskaya T.N., The effects of opioid neuropeptides and their derivatives in the regulation of behavioral activity in an ascending series of mammals, Oligopeptides As Regulators of Body Functions [in Russian], pp. 43-65, (1987)

[6]

Klusha V.E., Peptide Regulators of Brain Functions [in Russian], (1984)

[7]

Salieva A., Likhacheva L.V., Met-enkephalin restores self-stimulation behavior in rabbits after lesioning of hypothalamic nuclei, Byull. Éksp. Biol. Med., 63, 2, (1992)

[8]

Sollertinskaya T.N., Obidova M.D., The effects of the opioid neuropeptides met-enkephalin and β-endorphin on conditioned reflex activity in hedgehogs, Fiziol. Zh. SSSR, 77, 10, pp. 10-19, (1991)

[9]

Sudakov K.V., Neuropeptides in central mechanisms of food-related behavior, Usp. Sovrem. Biol., 105, 1, pp. 41-44, (1988)

[10]

Shalyapina V.G., Adrenocorticotropin, Physiology of the Endocrine System (Handbook in Physiology) [in Russian], pp. 65-70, (1979)

← 1 2 3 →