Free Radicals in Rabbit Spinal Cord Ischemia: Electron Spin Resonance Spectroscopy and Correlation with SOD Activity

被引:18
作者
Vincenzo Lombardi [1 ]
Ladislav Valko [2 ]
Svorad Štolc [3 ]
Marián Valko [2 ]
Ol'ga Ondrejičková [3 ]
L'ubica Horáková [3 ]
Jan Plaček [4 ]
Antonio Troncone [5 ]
机构
[1] Department of Pathological Anatomy and Department of Experimental Oncology,Department of Physical Chemistry
[2] Bari Oncology Center,Institute of Veterinary Pathological Anatomy
[3] Slovak Technical University,undefined
[4] Institute of Experimental Pharmacology,undefined
[5] Slovak Academy of Sciences,undefined
[6] Dúbravská,undefined
[7] Polymer Institute,undefined
[8] Slovak Academy of Sciences,undefined
[9] Bari University,undefined
关键词
spinal cord ischemia; reperfusion; paraplegia; rabbit; free radicals; super oxide radical; electron spin resonance (ESR) spectroscopy; super oxide dismutase; conjugated dienes;
D O I
10.1023/A:1022597431593
中图分类号
学科分类号
摘要
1. In nonanesthetized rabbits temporal occlusion of the abdominal aorta was used to induce oxidative stress in the lower part of the body including distal segments of the spinal cord.
引用
收藏
页码:399 / 412
页数:13
相关论文
共 128 条
[1]  
Anderson D. K.(1985)Iron-induced lipid peroxidation in spinal cord: Protection with mannitol and methylprednisolone Free Rad. Biol. Med. 1 59-64
[2]  
Means E. D.(1966)ESR linewidth in solution. II. Analysis of spin-rotational relaxation data J. Chem. Phys. 44 169-174
[3]  
Atkins P. W.(1982)Biosynthesis of mitochondrial superoxide dismutase in Saccharomyces cerevisiae J. Biol. Chem. 257 2713-2718
[4]  
Kivelson D.(1970)Effect of ischemia and electroconvulsive shock on free fatty acid pool in the brain Biochim. Biophys. Acta 1970 1-10
[5]  
Author A. P.(1993)Application of 2D Mol. Chem. Neuropathol. 19 1-13
[6]  
Bazan N. G.(1994)H NMR spectroscopy to the study of the brain, spinal cord and sciatic nerve Free Rad. Biol. Med. 16 811-820
[7]  
Beloeil J. C.(1989)Postischemic inhibition of cerebral cortex pyruvate dehydrogenase Free Rad. Biol. Med. 6 289-301
[8]  
Gillet B.(1970)Central nervous system trauma and stroke I. Biochemical considerations for oxygen radical formation and lipid peroxidation Eur. J. Biochem. 15 352-355
[9]  
Fedeli O.(1989)Oxygen-17 hyperfine splitting in the electron paramagnetic resonance spectrum of enzymatically generated superoxide Magn. Res. Med. 9 126-131
[10]  
Berenger G.(1993)Cerebral metabolism in man after acute stroke: New observations using localized proton NMR spectroscopy Free Rad. Biol. Med. 14 243-250