Insights into pathogenesis and treatment of cytokines in cardiomyopathy

被引：27

作者：

Vadlamani L. ^{[1
]}

Abraham W.T. ^{[1
]}

机构：

[1] Section of Heart Failure and Cardiac Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0542

来源：

Current Cardiology Reports | 2000年 / 2卷 / 2期

关键词：

Heart Failure; Chronic Heart Failure; Atrial Natriuretic Peptide; Bosentan; Cardiac Myxoma;

D O I：

10.1007/s11886-000-0008-3

中图分类号：

学科分类号：

摘要：

Our understanding of the pathophysiology of chronic heart failure is rapidly expanding. recent investigations suggest a role for various proinflammatory and vasoconstrictive cytokines in the development and progression of the disease. In particular, tumor necrosis factor-a, interlukin-6, and endothelin have all been implicated in heart failure desease progression. These cytokines appear to be activated in response to a remodeling, induction of programmed cell death, neurohormonal activation, and hemodynamics, these agents cause a variety of deleterious effects in the setting of ventricular dysfunction. Investigational inhibitors and antagonists of these substances show promise for the future treatment of heart failure. Copyright © 2000 by Current Science Inc.

引用

页码：120 / 128

页数：8

共 91 条

[1]

Mann D.L., Young J.B., Basic mechanisms in congestive heart failure: Understanding the role of proinflammatory cytokines, Chest, 105, pp. 897-904, (1994)

[2]

Neta R., Oppenheim J.J., Durum S.K., The cytokine concept: Historical perspectives and current status of the clonal cytokines, Lymphokines and the Immune Response, pp. 29-42, (1990)

[3]

Carswell E.A., Old L.J., Kassell R.L., Et al., An endotoxin-induced serum factor that causes necrosis of tumors, Proc Natl Acad Sci U S A, 72, pp. 3666-3670, (1975)

[4]

Beutler B., Milsark I.W., Cerami A.C., Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264, 7 Cells. J Exp Med, 161, pp. 984-995, (1985)

[5]

Beutler B., Cerami A.C., Cachectin and tumor necrosis factor as two sides of the same biological coin, Nature, 320, pp. 584-588, (1986)

[6]

Beutler B., Milsark I.W., Cerami A.C., Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin, Science, 229, pp. 869-871, (1985)

[7]

Finkel M.S., Oddis C.V., Jacob T.D., Et al., Negative inotropic effects of cytokines on the heart mediated by nitric oxide, Science, 257, pp. 387-389, (1992)

[8]

Murray D.R., Freeman G.L., Tumor necrosis factor-alpha induces a biphasic effect on myocardial contractility in conscious dogs, Circ Res, 78, pp. 154-160, (1996)

[9]

Levine B., Kalman J., Mayer L., Et al., Elevated circulating levels of tumor necrosis factor in severe chronic heart failure, N Engl J Med, 323, pp. 236-241, (1990)

[10]

McMurray J., Abdullah I., Dargie H.J., Shapiro D., Increased concentrations of tumor necrosis factor in " cachectic" patients with severe chronic heart failure, Br Heart J, 66, pp. 356-358, (1991)

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