Aortic valve sclerosis as a marker of active atherosclerosis

被引：46

作者：

Branch K.R. ^{[1
]}

O'Brien K.D. ^{[1
]}

Otto C.M. ^{[1
]}

机构：

[1] Division of Cardiology, University of Washington Medical Center, Seattle, WA 98195-6422

来源：

Current Cardiology Reports | 2002年 / 4卷 / 2期

关键词：

Aortic Valve; Aortic Stenosis; Aortic Valve Stenosis; Aortic Valve Disease; Calcific Aortic Valve;

D O I：

10.1007/s11886-002-0022-8

中图分类号：

学科分类号：

摘要：

Aortic sclerosis is a calcific disease of the aortic valvular leaflets defined as focal leaflet thickening without significant obstruction to left ventricular outflow. Several clinical factors are associated with calcific aortic valve disease, including male sex, smoking, hypertension, age, hypercholesterolemia, and diabetes. Histologic and biochemical studies suggest similarities between the mechanisms involved in the development of aortic sclerosis and atherosclerosis, suggesting these two diseases may share common pathophysiologic mechanisms. In a recent prospective trial, the presence of aortic sclerosis was associated with an approximately 50% increase in cardiovascular mortality and myocardial infarction, even after correction for age, gender, known coronary artery disease, and clinical factors associated with a aortic sclerosis. Copyright © 2002 by Current Science Inc.

引用

页码：111 / 117

页数：6

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