Inflammatory markers and stroke

被引：35

作者：

Elkind M.S.V. ^{[1
]}

机构：

[1] Department of Neurology, Columbia University, New York-Presbyterian Hospital, New York, NY 10032

来源：

Current Cardiology Reports | 2009年 / 11卷 / 1期

关键词：

Ischemic Stroke; Stroke Patient; Stroke Risk; Carotid Plaque; Cardiovascular Health Study;

D O I：

10.1007/s11886-009-0003-2

中图分类号：

学科分类号：

摘要：

Basic and animal research implicate inflammatory mechanisms in the pathogenesis and progression of atherosclerosis, plaque rupture, thrombosis, and stroke. Inflammatory biomarkers, particularly high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2, have been identified as potential predictors of stroke risk and prognosis. Infections may also precipitate stroke. Medications, especially hydroxymethylglutaryl coenzyme A reductase inhibitors (statins), reduce inflammatory marker levels independently of lipid effects, and the ability of statins to reduce coronary events and stroke correlates with their effect on inflammatory biomarkers. Vaccination against influenza may also reduce stroke risk. Determining whether reduction of biomarkers reduces risk of recurrent stroke, however, requires further study before inflammatory markers become a routine part of the evaluation of stroke patients. © 2009 by Current Medicine Group LLC.

引用

页码：12 / 20

页数：8

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