Correlation of serum homocysteine levels with the severity of coronary artery disease

被引：153

作者：

Shenoy V. ^{[1
]}

Mehendale V. ^{[2
]}

Prabhu K. ^{[1
]}

Shetty R. ^{[3
]}

Rao P. ^{[1
]}

机构：

[1] Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal

[2] Department of Applied Nutrition, Dietics Welcome Group School of Hotel Management, Manipal University, Manipal

[3] Department of Cardiology, Kasturba Medical College, Manipal University, Manipal

来源：

Indian Journal of Clinical Biochemistry | 2014年 / 29卷 / 3期

关键词：

Coronary artery disease (CAD); Gensini scoring system; Homocysteine;

D O I：

10.1007/s12291-013-0373-5

中图分类号：

学科分类号：

摘要：

Coronary artery disease (CAD) has become the most common cause of mortality in the entire world. Homocysteine is implicated as an early atherosclerotic promoter. We studied the relationship between levels of serum homocysteine with severity of coronary artery disease. Total of 70 subjects who scheduled for coronary angiogram consented to participate in this study. In all the patients Gensini scoring system was used to assess the severity of CAD. Venous samples were taken from the patients in fasting state before angiography. Homocysteine levels in patients were measured by enzyme linked immunosorbant method and were compared with respective Genseni scores of participants. Fasting serum homocysteine levels in CAD patients were significantly higher than patients without coronary artery disease (p < 0.001). Also Homocyseine levels correlated significantly with increasing severity of CAD (p < 0.001). Serum homocysteine levels correlated well with the severity of CAD. © 2013 Association of Clinical Biochemists of India.

引用

页码：339 / 344

页数：5

共 25 条

[1]

Patil S.S., Joshi R., Gupta G., Reddy M.V.R., Pai M., Kalantri S.P., Risk factors for acute myocardial infarction in a rural population of central India: A hospital-based case-control study, National Medical Journal of India, 17, 4, pp. 189-194, (2004)

[2]

Goel P.K., Bharti B.B., Pandey C.M., Singh U., Tewari S., Kapoor A., Garg N., Sinha N., A tertiary care hospital-based study of conventional risk factors including lipid profile in proven coronary artery disease, Indian Heart Journal, 55, 3, pp. 234-240, (2003)

[3]

Fuster V., Voute J., MDGs: Chronic diseases are not on the agenda, Lancet, 366, 9496, pp. 1512-1514, (2005)

[4]

Upadhyaya R.P., An overview of the burden of non-communicable diseases in India, Iran J Public Health, 41, 3, pp. 1-8, (2012)

[5]

Goyal A., Yusuf S., The burden of cardiovascular disease in the Indian subcontinent, Indian Journal of Medical Research, 124, 3, pp. 235-244, (2006)

[6]

Smith Jr. S.C., Current and future directions of cardiovascular risk prediction, Am J Cardiol, 97, (2006)

[7]

Mallinow M.R., Hyperhomocysteinemia A common and easily reversible risk factor for occlusive atherosclerosis, Circulation, 81, 6, pp. 2004-2006, (1990)

[8]

Abraham R., Joseph John M., Calton R., Dhanoa J., Raised serum homocysteine levels in patients of coronary artery disease and the effect of vitamin B12 and folate on its concentration, Indian J Clin Biochem, 21, 1, pp. 95-100, (2006)

[9]

Chambers J.C., Obeid O.A., Refsum H., Ueland P., Hackett D., Hooper J., Turner R.M., Thompson S.G., Kooner J.S., Plasma homocysteine concentrations and risk of coronary heart disease in UK Indian Asian and European men, Lancet, 355, 9203, pp. 523-527, (2000)

[10]

Refsum H., Nurk E., Smith A.D., Ueland P.M., Gjesdal C.G., Bjelland I., Tverdal A., Tell G.S., Nygard O., Vollset S.E., The Hordaland Homocysteine Study: A community-based study of homocysteine, its determinants, and associations with disease, Journal of Nutrition, 136, 6, (2006)

← 1 2 3 →