Effect of Xingnaojing injection on hippocampal N-methyl-D-aspartic acid receptors of focal cerebral ischemia in rats

被引：8

作者：

Shen Si-yu

Cai Ding-fang

Chen Wei-hua

Liu Jing

Chen Hu

Ying Jian

机构：

[1] Nanjing University,Department of Traditional Chinese Medicine, Jinling Hospital

[2] Huashan Hospital Affiliated to Fudan University,Institute of Integrated Traditional and Western Medicine

来源：

Chinese Journal of Integrative Medicine | 2003年 / 9卷 / 1期

关键词：

Xingnaojing injection; focal cerebral ischemia; N-methyl-D-aspartic acid receptor; neuro-protection;

D O I：

10.1007/BF02836356

中图分类号：

学科分类号：

摘要：

Objective: To observe and elucidate the neuroprotective effect of Xingnaojing (XNJ) injection on hippocampal N-methyl-D-aspartic acid (NMDA) receptors of focal cerebral ischemia in rats.Methods: Cerebral ischemia was established by occluding the middle cerebral artery with an intraluminal suture technique in rats. Neurological deficit score, infarct volume and quantity of NMDA receptors were estimated in all groups and compared.Results: After being treated with XNJ, the score decreased in the initial 6 hours and infarct volume decreased in 24 hours. And within 24 hours, the quantity of NMDA receptors obviously decreased compared with the model group (P<0. 01). It indicated that XNJ could ameliorate neurological behavior of middle cerebral artery occlusion rats and down-regulate the expression of hippocampal NMDA receptors.Conclusion: The neuroprotective effect of XNJ on focal cerebral ischemia is possibly related to down-regulating the expression of NMDA receptors in rats.

引用

页码：49 / 52

页数：3

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