Inflammation and atherosclerosis

被引：98

作者：

Shishehbor M.H. ^{[1
]}

Bhatt D.L. ^{[1
]}

机构：

[1] Dept. of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195

来源：

Current Atherosclerosis Reports | 2004年 / 6卷 / 2期

关键词：

Atherosclerosis; Acute Coronary Syndrome; Clopidogrel; Atherosclerotic Plaque; Plaque Rupture;

D O I：

10.1007/s11883-004-0102-x

中图分类号：

学科分类号：

摘要：

Inflammation plays a pivotal role in all stages of atherogenesis, from foam cell to plaque formation to rupture and ultimately to thrombosis. Insight gained from recent basic and clinical data linking inflammation to atherosclerosis has yielded important diagnostic and prognostic information. Low-grade chronic inflammation as measured by high sensitivity C-reactive protein predicts future risk of acute coronary syndrome independent of traditional cardiovascular risk factors. In addition, individuals with higher inflammatory burden" gain the largest absolute risk reduction with aggressive risk-lowering therapy. The link between inflammation and atherosclerosis provides a new venue for future pharmacologic agents that may slow the progression of atherosclerosis by inhibiting inflammation. Copyright© 2004 by Current Science Inc."

引用

页码：131 / 139

页数：8

共 103 条

[1]

Libby P., Ridker P.M., Maseri A., Inflammation and atherosclerosis, Circulation, 105, pp. 1135-1143, (2002)

[2]

Libby P., Molecular bases of the acute coronary syndromes, Circulation, 91, pp. 2844-2850, (1995)

[3]

Qiao J.H., Fishbein M.C., The severity of coronary atherosclerosis at sites of plaque rupture with occlusive thrombosis, J. Am. Coll. Cardiol., 17, pp. 1138-1142, (1991)

[4]

Giroud D., Li J.M., Urban P., Et al., Relation of the site of acute myocardial infarction to the most severe coronary arterial stenosis at prior angiography, Am. J. Cardiol., 69, pp. 729-732, (1992)

[5]

Rioufol G., Finet G., Ginon I., Et al., Multiple atherosclerotic plaque rupture in acute coronary syndrome: A three-vessel intravascular ultrasound study, Circulation, 106, pp. 804-808, (2002)

[6]

Burke A.P., Tracy R.P., Kolodgie F., Et al., Elevated C-reactive protein values and atherosclerosis in sudden coronary death: Association with different pathologies, Circulation, 105, pp. 2019-2023, (2002)

[7]

Buffon A., Biasucci L.M., Liuzzo G., Et al., Widespread coronary inflammation in unstable angina, N. Engl. J. Med., 347, pp. 5-12, (2002)

[8]

Steinberg D., Parthasarathy S., Carew T.E., Et al., Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity, N. Engl. J. Med., 320, pp. 915-924, (1989)

[9]

Chisolm III G.M., Hazen S.L., Fox P.L., Cathcart M.K., The oxidation of lipoproteins by monocytes-macrophages. Biochemical and biological mechanims, J. Biol. Chem., 274, pp. 25959-25962, (1999)

[10]

Chisolm G.M., Steinberg D., The oxidative modification hypothesis of atherogenesis: An overview, Free Radic. Biol. Med., 28, pp. 1815-1826, (2000)

← 1 2 3 4 5 6 7 8 9 10 →