The complete genome sequence of the gastric pathogen Helicobacter pylori

被引：2910

作者：

Jean-F. Tomb ^{[1
]}

Owen White ^{[1
]}

Anthony R. Kerlavage ^{[1
]}

Rebecca A. Clayton ^{[1
]}

Granger G. Sutton ^{[1
]}

Robert D. Fleischmann ^{[1
]}

Karen A. Ketchum ^{[1
]}

Hans Peter Klenk ^{[1
]}

Steven Gill ^{[1
]}

Brian A. Dougherty ^{[1
]}

Karen Nelson ^{[1
]}

John Quackenbush ^{[1
]}

Lixin Zhou ^{[1
]}

Ewen F. Kirkness ^{[1
]}

Scott Peterson ^{[1
]}

Brendan Loftus ^{[1
]}

Delwood Richardson ^{[1
]}

Robert Dodson ^{[1
]}

Hanif G. Khalak ^{[1
]}

Anna Glodek ^{[1
]}

Keith McKenney ^{[1
]}

Lisa M. Fitzegerald ^{[1
]}

Norman Lee ^{[1
]}

Mark D. Adams ^{[1
]}

Erin K. Hickey ^{[1
]}

Douglas E. Berg ^{[2
]}

Jeanine D. Gocayne ^{[1
]}

Teresa R. Utterback ^{[1
]}

Jeremy D. Peterson ^{[1
]}

Jenny M. Kelley ^{[1
]}

Matthew D. Cotton ^{[1
]}

Janice M. Weidman ^{[1
]}

Claire Fujii ^{[1
]}

Cheryl Bowman ^{[1
]}

Larry Watthey ^{[1
]}

Erik Wallin ^{[3
]}

William S. Hayes ^{[4
]}

Mark Borodovsky ^{[4
]}

Peter D. Karp ^{[5
]}

Hamilton O. Smith ^{[6
]}

Claire M. Fraser ^{[1
]}

J. Craig Venter ^{[1
]}

机构：

[1] The Institute for Genomic Research,Department of Molecular Biology

[2] School of Medicine,Department of Biochemistry

[3] Washington University St Louis,Department of Molecular Biology and Genetics

[4] Arrhenius Laboratory,undefined

[5] Stockholm University,undefined

[6] School of Biology,undefined

[7] SRI International,undefined

[8] Artificial Intelligence Center,undefined

[9] School of Medicine,undefined

[10] Johns Hopkins University,undefined

来源：

Nature | 1997年 / 388卷 / 6642期

关键词：

D O I：

10.1038/41483

中图分类号：

学科分类号：

摘要：

Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host–pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.

引用

页码：539 / 547

页数：8