Oxidative stress markers and C-reactive protein in end-stage renal failure patients on dialysis

被引：59

作者：

Elisabeth C. Samouilidou

Eirini J. Grapsa

Ioannis Kakavas

Antonios Lagouranis

Basilis Agrogiannis

机构：

[1] Biochemical Department, Athens

[2] Renal Unit 'Alexandra' Hospital, 11528 Athens

[3] Renal Unit 'Ippokration' Hospital, Athens

[4] Renal Unit 'Areteion' Hospital, Athens

来源：

International Urology and Nephrology | 2003年 / 35卷 / 3期

关键词：

4-hydroxyalkenals; C-reactive protein; Hemodialysis; Malonaldehyde; Peritoneal dialysis; Total antioxidant capacity;

D O I：

10.1023/B:UROL.0000022846.83505.3f

中图分类号：

学科分类号：

摘要：

Objective: The inflammatory status is a well-documented factor influencing the development of oxidative stress in dialysis patients. This study intends to evaluate the inflammatory activity and the plasma levels of total antioxidant capacity (TAC) and lipid peroxidation products in patients on peritoneal dialysis (PD), by comparison with hemodialysis (HD) patients. Patients and Methods: Plasma concentration of TAC, lipid peroxidation products and C-reactive protein (CRP) were measured in 24 patients on PD, 32 HD patients (pre and post treatment) and 16 normal controls (NC). Results: All patients had higher levels of TAC and lipid peroxidation products than NC (p < 0.001). Patients on PD, had similar levels to patients before HD but significantly higher (p < 0.001) than those post HD. The CRP concentration was higher in HD than in PD patients (p < 0.05). The percentage of patients with CRP > 10 mg/l was 48% in HD patients and 21% in PD patients. No correlation was observed between CRP and TAC nor CRP and MDA levels. Conclusions: We conclude that although PD and HD patients show an equal susceptibility in oxidative stress, CRP levels are higher in HD patients and this is indicative of a higher degree of inflammatory activity in these patients. © 2004 Kluwer Academic Publishers.

引用

页码：393 / 397

页数：4

共 24 条

[1]

Tetta C., Biasoli S., Schiavon R., Inguaggiato P., David S., An overview of hemodialysis and oxidative stress, Blood Purif., 17, pp. 118-126, (1999)

[2]

Fiorillo C., Oliviero C., Rizzuti G., Nediani C., Pacini A., Oxidative stress and antioxidant defenses in renal patients receiving regular hemodialysis, Clin. Chem. Lab. Med., 36, pp. 149-153, (1998)

[3]

Morena M., Cristol J.P., Canaud B., Why hemodialysis patients are in prooxidant state? What could be done to correct the pro/antioxidant imbalance?, Blood Purif., 18, pp. 191-199, (2000)

[4]

Mimic-Oka J., Simic T., Djukanovic L., Reljic Z., Davicevic Z., Alteration in plasma antioxidant capacity in various degrees of chronic renal failure, Clin. Nephrol., 51, pp. 233-241, (1999)

[5]

Donica H., Evaluation of lipids peroxidation products vs. proinflammatory cytokines in hemodialyzed patients, Ren. Fail., 23, pp. 231-238, (2001)

[6]

Jackson P., Loughrey C., Lightbody J., Mc Namee P., Young I., Effect of hemodialysis on total antioxidant capacity and serum antioxidants in patients with chronic renal failure, Clin. Chem., 41, pp. 1135-1138, (1995)

[7]

Dasgupta A., Hussain S., Ahmad S., Increased lipid peroxidation in patients on maintenance hemodialysis, Nephron., 60, pp. 56-59, (1992)

[8]

Daschner M., Lenhartz H., Botticher D., Schaffer F., Wollschlager M., Leichsenring M., Influence of dialysis on plasma lipid peroxidation products and antioxidant levels, Kidney International, 50, pp. 1268-1272, (1996)

[9]

Docci D., Bilancioni R., Busocardi A., Baldati L., Capponcini C., Elevated levels of C-reactive protein in hemodialysis patients, Nephron, 56, pp. 364-367, (1990)

[10]

Nguyen-Koha T., Massy Z.A., De Bandt J.P., Kebede M., Oxidative stress in hemodialysis: Role of inflammation and duration of dialysis treatment, Nephrol. Dial Tranplant, 16, pp. 335-340, (2001)

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